Heart Disease News, Articles & Information

Homocysteine is an amino acid that is becoming an increasingly important risk factor for coronary heart disease and strokes. Homocysteine is believed to degrade and inhibit the formation of the major components of arteries - collagen, elastin & proteoglycans leading to increased rates of arterial decline and conditions such as atherosclerosis

Several studies have demonstrated the link between elevated homocysteine levels and increased risk of cardiovascular disease. The Hordaland homocysteine study is a Norwegian study involving over 18,000 individuals. The study found that individuals with higher than average homocysteine levels in the blood tended to have higher blood pressure and higher cholesterol levels and more importantly, were at a much higher risk of developing cardiovascular disease than individuals with lower homocysteine levels.

The following graph demonstrates the effect of high homocysteine levels on both overall mortality and on cardiovascular hospitalizations. As can be seen, as homocysteine levels increase, the odds of both dying or being hospitalized through a cardiovascular problem increase.

The B Vitamins, particularly folic acid, B6 and B12, help convert homocysteine into useful proteins. A deficiency in the B vitamins is associated with high homocysteine levels. Studies have found that both folate and vitamin B12 levels in the blood are inversely correlated with plasma homocysteine levels.

Foods rich in vitamin B-6 include tuna cauliflower, bananas and asparagus. Good sources of folic acid (folate) include: spinach, dried beans and peas, citrus fruits turnips and broccoli. Foods rich in vitamin B-12 include most meats, especially poultry and fish, dairy produce and eggs.

It is recommended that people consume at least 2 to 3 servings of foods rich in B-vitamins daily. Those over the age of 50 should consider taking a vitamin B-12 supplement as the bodies ability to absorb the vitamin decreases with age. It is estimated that as many as a quarter of those aged over the age of 50 maybe deficient in vitamin B-12.